Why The Ribbon Representation Of Human Glp Continues to Amaze Us
Bioactivity analysis of human GLP-1R agonist (RLU). This reporter cell was incubated with serial dilutions of Tirzepatide (a dual GLP-1R and GIPR agonist). The EC50 of Tirzepatide was approximately 1.11 nM.
Expression analysis of human GLP-1R on Human GLP-1R (Luc) HEK293 Reporter Cell by FACS.Response to human GLP-1 (FOLD). This reporter cell was stimulated with serial dilutions of human GLP-1. The max induction fold was approximately 493.65. Passage Stability.
The Ribbon Representation Of Human Glp
The ribbon representation of the apo receptor shows the transmembrane helices TM1 and TM6 relatively straight (Wu et al., 2020), while that of the GLP-1 peptide bound form shows twists (in TM1) and a kink (in TM6) (Zhang et al., 2020).
